Cell migration controls developmental processes (gastrulation and tissue patterning), tissue
homeostasis (wound repair and inflammatory responses), and the pathobiology of diseases …

Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …

Cell migration and invasion is a key driving factor for providing essential cellular functions
under physiological conditions or the malignant progression of tumors following downward …

Simple Summary Cell migration is an essential biological process that regulates both
development and diseases, such as cancer metastasis. Therefore, understanding the factors …

Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is often lethal because it is
highly invasive and metastasizes rapidly. The actin-bundling protein fascin has been …

Single cell branching during development in vertebrates is typified by neuronal branching to
form neurites and vascular branches formed by sprouting angiogenesis. Neurons and …

Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be
separated by micron-scale gaps. For membranes to protrude and reattach across a gap …

Abstract Myosin-X (Myo10) is an unconventional myosin best known for its striking
localization to the tips of filopodia. Despite the broad expression of Myo10 in vertebrate …

Directional migration of neural crest (NC) cells is essential for patterning the vertebrate
embryo, including the craniofacial skeleton. Extensive filopodial protrusions in NC cells are …

Previous cell biological studies demonstrate that the actin bundling protein fascin1 regulates
cell motility, migration and invasion. Human studies demonstrate that fascin1 is upregulated …