Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
The amyloid-β pathway in Alzheimer's disease
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …
Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval
M Tolar, S Abushakra, JA Hey, A Porsteinsson… - Alzheimer's research & …, 2020 - Springer
The body of evidence suggesting a causative, initiating role of beta amyloid (Aβ) in the
pathogenesis of Alzheimer's disease (AD) is substantial. Yet, only a few anti-amyloid agents …
pathogenesis of Alzheimer's disease (AD) is substantial. Yet, only a few anti-amyloid agents …
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
DA Butterfield, B Halliwell - Nature Reviews Neuroscience, 2019 - nature.com
Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …
A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease
Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …
Neuronal cell death
M Fricker, AM Tolkovsky, V Borutaite… - Physiological …, 2018 - journals.physiology.org
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …
especially important because of the limited capacity of adult neurons to proliferate or be …
The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Microglia in Alzheimer's disease
H Sarlus, MT Heneka - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Microglia are brain-resident myeloid cells that mediate key functions to support the CNS.
Microglia express a wide range of receptors that act as molecular sensors, which recognize …
Microglia express a wide range of receptors that act as molecular sensors, which recognize …