The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …

Polarized cells such as epithelial cells and neurons exhibit different plasma membrane
domains with distinct protein compositions. Recent studies have shown that sorting of …

The AP (adaptor protein) complexes are heterotetrameric protein complexes that mediate
intracellular membrane trafficking along endocytic and secretory transport pathways. There …

The restrictive nature of the blood–brain barrier means that cellular machinery must be in
place to deliver macromolecules to the brain. This is achieved by transcytosis which is more …

Mouse models of cancers are routinely used to study cancer biology. However, it remains
unclear whether carcinogenesis in mice is driven by the same spectrum of genomic …

Adaptor protein (AP) complexes are heterotetramers that select cargo for inclusion into
transport vesicles. Five AP complexes (AP-1 to AP-5) have been described, each with a …

Cadherin-based adherens junctions are conserved structures that mediate epithelial cell–
cell adhesion in invertebrates and vertebrates. Despite their pivotal function in epithelial …

Protein coats are supramolecular complexes that assemble on the cytosolic face of
membranes to promote cargo sorting and transport carrier formation in the endomembrane …

Toll-like receptors (TLRs) are membrane-bound microbial sensors that mediate important
host-to-microbe responses. Cell biology aspects of TLR function have been intensively …

The epithelial-mesenchymal transition (EMT) is an acknowledged cellular transition process
in which epithelial cells acquire mesenchymal-like properties that endow cancer cells with …