MicroRNAs (miRNAs) are a series of promising molecules that could regulate gene
expression, while its expression level and type are strictly related to the early diagnosis …

Breast cancer affects one in seven women worldwide during their lifetime. Widespread
mammographic screening programs and education campaigns allow for early detection of …

Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human
colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice …

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …

The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using
single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients' …

The RNA N6-methyladenosine (m6A) writer methyltransferase-like 3 (METTL3) is
upregulated in many types of cancer and promotes cancer progression by increasing …

Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …

Determining how cells vary with their local signaling environment and organize into distinct
cellular communities is critical for understanding processes as diverse as development …

The factors that influence nanoparticle fate in vivo following systemic delivery remain an
area of intense interest. Of particular interest is whether labeling with a cancer-specific …

Background The human leucocyte antigen (HLA) complex controls adaptive immunity by
presenting defined fractions of the intracellular and extracellular protein content to immune …