Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …

Background The pathogenesis of neuropathic pain and the reasons for the prolonged
unhealing remain unknown. Increasing evidence suggests that sex oestrogen differences …

Abstract Gamma-aminobutyric acid (GABA), a non-protein-producing amino acid
synthesized from the excitatory amino acid glutamate via the enzyme glutamic acid …

Despite the overwhelming female-predominance in chronic pain disorders, preclinical pain
studies have historically excluded females as research subjects. Male-biased explanations …

Chronic pain is a prevalent condition with a multifaceted pathogenesis, where epigenetic
modifications, particularly DNA methylation, might play an important role. This review delves …

The purpose of this study was to investigate the mechanism of antiallodynic effect of
tizanidine in neuropathic rats. Spinal nerve ligation reduced withdrawal threshold which was …

Multiple studies indicate that adult male rodents perform better than females on spatial
problems and have a lower threshold for long-term potentiation (LTP) of hippocampal CA3 …

The loss of GABAergic inhibition is a mechanism that underlies neuropathic pain. Therefore,
rescuing the GABAergic inhibitory tone through the activation of GABA A receptors is a …

Traumatic brain injury (TBI) leads to changes in the neural circuitry of the hippocampus that
result in chronic learning and memory deficits. However, effective therapeutic strategies to …