Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide
variety of key biological processes. It plays an essential role in cellular energy metabolism …

Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which
encode the sodium-dependent inorganic phosphate (Pi) cotransport proteins 2a–2c, has …

Npt2 encodes a renal-specific, brush-border membrane Na+-phosphate (Pi) cotransporter
that is expressed in the proximal tubule where the bulk of filtered Pi is reabsorbed. Mice …

FGF‐23 is a novel regulator of phosphate metabolism. We studied the regulation of FGF‐23
by dietary phosphate in 66 men and women using two assays. Dietary phosphate restriction …

Klotho mutant mouse (kl-/-), a mouse model for human aging, exhibits various phenotypes in
a wide range of organs including arteriosclerosis, neural degeneration, skin and gonadal …

Sodium (Na+) is the principal osmole in extracellular fluid; as such, the total body content of
Na+ and Cl-, its primary anion, determine the extracellular fluid volume. Renal excretion or …

Renal proximal tubular reabsorption of Pi is a key element in overall Pi homeostasis, and it
involves a secondary active Pi transport mechanism. Among the molecularly identified …

Phosphate plays essential roles in many biological processes, and the serum phosphate
level is tightly controlled. Chronic hypophosphatemia causes impaired mineralization of the …

The mammalian kidney is multiform. The basic architecture is best understood in the
unipapillary kidney, which is common in all small species. A coronal section of this kidney …

Phosphate is an essential nutrient for life and is a critical component of bone formation, a
major signaling molecule, and structural component of cell walls. Phosphate is also a …