Cholestasis: Exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies

L Yu, Y Liu, S Wang, Q Zhang, J Zhao, H Zhang… - Gut …, 2023 - Taylor & Francis
Cholestasis is a condition characterized by the abnormal production or excretion of bile, and
it can be induced by a variety of causes, the factors of which are extremely complex …

[HTML][HTML] Sex-dependent differences in cholestasis: why estrogen signaling may be a key pathophysiological driver

AG Ismail, L Kennedy, H Francis - The American Journal of Pathology, 2023 - Elsevier
Primary Biliary Cholangitis (PBC) and Primary Sclerosing Cholangitis (PSC) are cholestatic
liver diseases with significant clinical impact with debilitating symptomology and mortality …

[HTML][HTML] Ginsenoside Rg1 alleviates ANIT-induced cholestatic liver injury by inhibiting hepatic inflammation and oxidative stress via SIRT1 activation

Q Gao, G Li, Y Zu, Y Xu, C Wang, D Xiang, W He… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Ginseng (Panax ginseng CA Mey) is a common
traditional Chinese medicine used for anti-inflammation, treating colitis, type 2 diabetes …

[HTML][HTML] Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver

TS Andrews, D Nakib, CT Perciani, XZ Ma, L Liu… - Journal of …, 2024 - Elsevier
Background & Aims Primary sclerosing cholangitis (PSC) is an immune-mediated
cholestatic liver disease for which there is an unmet need to understand the cellular …

Specificity proteins (SP) and Krüppel-like factors (KLF) in liver physiology and pathology

VG Yerra, K Drosatos - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver acts as a central hub that controls several essential physiological processes
ranging from metabolism to detoxification of xenobiotics. At the cellular level, these …

Primary biliary cholangitis: primary autoimmune disease or primary secretory defect

A Floreani, D Gabbia, S De Martin - Expert Review of …, 2023 - Taylor & Francis
Introduction Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease
characterized by the immune-mediated destruction of small and medium intrahepatic bile …

Features of lipid metabolism disorders in primary biliary cholangitis

VI Reshetnyak, IV Maev - Biomedicines, 2022 - mdpi.com
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an
autoimmune liver disease that mostly affects women. A progressive disorder in the …

[HTML][HTML] Коморбидность пациентов с хроническими неинфекционными заболеваниями в практике врача-терапевта. Евразийское руководство

ОМ Драпкина, АВ Концевая, АМ Калинина… - Кардиоваскулярная …, 2024 - cyberleninka.ru
[Драпкина ОМ—д. м. н., профессор, академик РАН, главный внештатный специалист
Минздрава по терапии и общей врачебной практике, директор, ФГБУ" НМИЦ ТПМ" …

Bile acids in autoimmune liver disease: unveiling the nexus of inflammation, inflammatory cells, and treatment strategies

T Zhou, AG Ismail, H Francis - Cells, 2023 - mdpi.com
As bile acids not solely play an essential role in nutrition absorption, but also in regulating
metabolic functions as well as immune response, bile acids and their signaling pathways …

Bioinformatic analysis identified novel candidate genes with the potentials for diagnostic blood testing of primary biliary cholangitis

HN Pham, L Pham, K Sato - Plos one, 2023 - journals.plos.org
Primary biliary cholangitis (PBC) is an autoimmune disorder characterized by intrahepatic
bile duct destruction and cholestatic liver injury. Diagnosis of PBC is generally based on the …