Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …

Insulin is a therapeutically relevant molecule with use in treating diabetes patients.
Unfortunately, it undergoes a range of untoward and often unpredictable physical …

Insulin-loaded nanoparticles were prepared by ionotropic pre-gelation of alginate with
calcium chloride followed by complexation between alginate and chitosan. The influence of …

The overall objective of our research is to produce polyanion/chitosan nanoparticulate oral
delivery systems for insulin. Specific objectives of the present study were to study dextran …

Motivation Understanding the molecular mechanisms of thermal stability is a challenge in
protein biology. Indeed, knowing the temperature at which proteins are stable has important …

Hypothesis: Oral insulin administration is not actually effective due to insulin rapid
degradation, inactivation and digestion by proteolytic enzymes which results in low …

Strict storage recommendations for insulin are difficult to follow in hot tropical regions and
even more challenging in conflict and humanitarian emergency settings, adding an extra …

Protein therapeutics are prone to lose their structure and bioactivity under various
environmental stressors. This study reports a facile approach using a nanoporous material …

The present paper focuses on the development and characterization of silica nanoparticles
(SiNP) coated with hydrophilic polymers as mucoadhesive carriers for oral administration of …

The traditional approach to investigating the partial unfolding and fibrillation of insulin, and
proteins at large, has involved use of the dyes 1-anilinonaphthalene-8-sulphonic acid (ANS) …