Regulation and metabolic functions of mTORC1 and mTORC2
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …
[HTML][HTML] EMT, cancer stem cells and autophagy; The three main axes of metastasis
G Babaei, SGG Aziz, NZZ Jaghi - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
JSL Yu, W Cui - Development, 2016 - journals.biologists.com
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …
mammalian target of rapamycin (mTOR) constitute the core components of the …
Autophagy, cancer stem cells and drug resistance
AG Smith, KF Macleod - The Journal of pathology, 2019 - Wiley Online Library
Autophagy is a cellular survival mechanism that is induced by cancer therapy, among other
stresses, and frequently contributes to cancer cell survival during long periods of dormancy …
stresses, and frequently contributes to cancer cell survival during long periods of dormancy …
[HTML][HTML] Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling
Cellular homeostasis and adaptation to various environmental conditions are importantly
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …
regulated by the sophisticated mechanism of autophagy and its crosstalk with Wnt signaling …
Functional characterization of SOX2 as an anticancer target
S Zhang, X Xiong, Y Sun - Signal transduction and targeted therapy, 2020 - nature.com
SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …
SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal …
Y Zhu, S Huang, S Chen, J Chen, Z Wang… - Cell death & …, 2021 - nature.com
Sex-determining region Y-box2 (SOX2), a master regulator of embryonic and induced
pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and …
pluripotent stem cells, drives cancer stem cells (CSCs) properties, fuels tumor initiation, and …
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling
Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells …
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
The existence of breast cancer stem cells (BCSCs) is a major reason underlying cancer
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …
metastasis and recurrence after chemotherapy and radiotherapy. Targeting BCSCs may …
A circular RNA protects dormant hematopoietic stem cells from DNA sensor cGAS-mediated exhaustion
P Xia, S Wang, B Ye, Y Du, C Li, Z Xiong, Y Qu, Z Fan - Immunity, 2018 - cell.com
Disrupting the balance between self-renewal and differentiation of hematopoietic stem cells
(HSCs) leads to bone marrow failure or hematologic malignancy. However, how HSCs …
(HSCs) leads to bone marrow failure or hematologic malignancy. However, how HSCs …