Endowed with the ability to actively suppress an immune response, regulatory T cells
(Tregs) hold the promise of halting ongoing pathogenic autoimmunity and restoring self …

Common dietary components including vitamins A and D, omega-3 and probiotics are now
widely accepted to be essential to protect against many diseases with an inflammatory …

The dynamics of CD4+ effector T cells (Teff cells) and CD4+ Foxp3+ regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine …

In type 1 diabetes, T cell-mediated death of pancreatic β cells produces insulin deficiency.
However, what attracts or restricts broadly autoreactive lymphocyte pools to the pancreas …

Polysaccharide A (PSA) derived from the human commensal Bacteroides fragilis is a
symbiosis factor that stimulates immunologic development within mammalian hosts. PSA …

Most treatments that prevent autoimmune diabetes in nonobese diabetic (NOD) mice require
intervention at early pathogenic stages, when insulitis is first developing. We tested whether …

Abstract Regulatory CD4+ CD25+ T cells (Tregs) are defective numerically and functionally
in autoimmune hepatitis (AIH). We have investigated and compared the mechanism of …

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by
lymphocytic infiltrates in portal tracts, selective destruction of biliary epithelial cells, and anti …

A progressive waning in Foxp3+ regulatory T cell (Treg) functions is thought to provoke
autoimmunity in the NOD model of type 1 diabetes (T1D). A deficiency in IL-2 is one of the …

FoxP3+ regulatory T cells (Tregs) protect against autoimmunity, type 1 diabetes (T1D) in
particular, prompting the hypothesis that a deficiency in Tregs is a critical determinant of …