Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

Tumor suppressor p53 plays a key role in tumor suppression. In addition to tumor
suppression, p53 is also involved in many other biological and pathological processes, such …

Background Copper ions are essential for cellular physiology. Cuproptosis is a novel
method of copper-dependent cell death, and the cuproptosis-based signature for glioma …

Abstract Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been
previously implicated in activities consistent with tumor suppression. Here we generated …

Mitochondria have a well-recognized role in the production of ATP and the intermediates
needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Background Hepatocellular carcinoma (HCC) is an aggressive malignant disease with poor
prognosis. Recent advances suggest the existence of cancer stem cells (CSCs) within liver …

Increased glutamine metabolism (glutaminolysis) is a hallmark of cancer and is recognised
as a key metabolic change in cancer cells. Breast cancer is a heterogeneous disease with …

Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of
cell death and has been primarily found in tumor cells. Previous studies have reported that …