Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Hypoxic tumor-associated macrophages (TAMs) acquire angiogenic and
immunosuppressive properties. Yet it remains unknown if metabolic changes influence …

The high metabolic rate required for tumor growth often leads to hypoxia in poorly-perfused
regions. Hypoxia activates a complex gene expression program, mediated by hypoxia …

Poor microenvironmental conditions are a characteristic feature of solid tumors. Such
conditions occur because the tumor vascular supply, which develops from the normal host …

Low oxygen gradients (hypoxia and anoxia) are important determinants of pathological
conditions under which the tissue blood supply is deficient or defective, such as in solid …

Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …

Background The effect of extracellular microenvironment (hypoxia and pH) has been
regarded as a key hallmark in cancer progression. The study aims to investigate the effects …

Cancer cells require a steady source of metabolic energy in order to continue their
uncontrolled growth and proliferation. Accelerated glycolysis is one of the biochemical …

Hypoxia is implicated in many aspects of tumor development, angiogenesis, and growth in
many different tumors. Brain tumors, particularly the highly aggressive glioblastoma …