The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Rejection is the major barrier to successful transplantation. The immune response to an
allograft is an ongoing dialogue between the innate and adaptive immune system that if left …

Abstract Background AMP-activated Protein Kinase (AMPK) is a stress-activated kinase that
protects against cardiomyocyte injury during ischemia and reperfusion. c-Jun N-terminal …

Review of mechanisms that might contribute to the fully reversible reduced immune function
that is present during hibernation. Mammalian hibernation consists of torpor phases when …

Cells respond to different types of stress by inhibition of protein synthesis and subsequent
assembly of stress granules (SGs), cytoplasmic aggregates that contain stalled translation …

Ischemia/reperfusion injury (IRI) associated with liver transplantation plays an important role
in the induction of graft injury. Prolonged cold storage remains a risk factor for liver graft …

Mammalian hibernation consists of periods of depressed metabolism and reduced body
temperature called “torpor” that are interspersed by normothermic arousal periods …

Hepatic steatosis is one of the most common hepatic disorders in developed countries. The
epidemic of obesity in developed countries has increased with its attendant complications …

Organ transplantation is a multifactorial process in which proper graft preservation is a
mandatory step for the success of the transplantation. Hypothermic preservation of …

Protection of endothelial cell function may explain the benefits of nonoxygenated
hypothermic machine perfusion (MP) for marginal kidney preservation. However, this …