[HTML][HTML] Inhibition of the main protease of SARS-CoV-2 (Mpro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds
I Antonopoulou, E Sapountzaki, U Rova… - Computational and …, 2022 - Elsevier
The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
has resulted in a long pandemic, with numerous cases and victims worldwide and enormous …
has resulted in a long pandemic, with numerous cases and victims worldwide and enormous …
Advances in the development of SARS-CoV-2 Mpro inhibitors
L Agost-Beltrán, S de la Hoz-Rodríguez, L Bou-Iserte… - Molecules, 2022 - mdpi.com
Since the outbreak of COVID-19, one of the strategies used to search for new drugs has
been to find inhibitors of the main protease (Mpro) of the virus SARS-CoV-2. Initially …
been to find inhibitors of the main protease (Mpro) of the virus SARS-CoV-2. Initially …
Synthesis and antimicrobial applications of ZnO nanostructures: A review
ZnO nanostructures (ZnO NSs) are able to provide significant antimicrobial activity, ensuring
high biocompatibility, good chemical stability, and low toxicity. Such versatility has led to …
high biocompatibility, good chemical stability, and low toxicity. Such versatility has led to …
[HTML][HTML] Medicinal chemistry strategies towards the development of non-covalent SARS-CoV-2 Mpro inhibitors
L Song, S Gao, B Ye, M Yang, Y Cheng, D Kang… - … Pharmaceutica Sinica B, 2024 - Elsevier
The main protease (M pro) of SARS-CoV-2 is an attractive target in anti-COVID-19 therapy
for its high conservation and major role in the virus life cycle. The covalent M pro inhibitor …
for its high conservation and major role in the virus life cycle. The covalent M pro inhibitor …
Metal-based strategies for the fight against COVID-19
The emerging COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has claimed over six million lives globally to date. Despite the …
coronavirus 2 (SARS-CoV-2) has claimed over six million lives globally to date. Despite the …
Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients?
In severe COVID-19, the levels of iron (Fe), copper (Cu), zinc (Zn) and selenium (Se), do not
only regulate host immune responses, but modify the viral genome, as well. While low serum …
only regulate host immune responses, but modify the viral genome, as well. While low serum …
The Effect of Circulating Zinc, Selenium, Copper and Vitamin K1 on COVID-19 Outcomes: A Mendelian Randomization Study
MK Sobczyk, TR Gaunt - Nutrients, 2022 - mdpi.com
Abstract Background & Aims: Previous results from observational, interventional studies and
in vitro experiments suggest that certain micronutrients possess anti-viral and …
in vitro experiments suggest that certain micronutrients possess anti-viral and …
Nutritional deficiencies that may predispose to long COVID
JV Schloss - Inflammopharmacology, 2023 - Springer
Multiple nutritional deficiencies (MND) confound studies designed to assess the role of a
single nutrient in contributing to the initiation and progression of disease states. Despite the …
single nutrient in contributing to the initiation and progression of disease states. Despite the …
Protective role of zinc in the pathogenesis of respiratory diseases
R Luan, D Ding, Q Xue, H Li, Y Wang… - European Journal of …, 2023 - nature.com
Respiratory diseases remain a major cause of morbidity and mortality worldwide. An
imbalance of zinc, an essential trace element, is associated with a variety of lung diseases …
imbalance of zinc, an essential trace element, is associated with a variety of lung diseases …
Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection
Gastrointestinal effects associated with Coronavirus Disease 2019 (COVID-19) are highly
variable for reasons that are not understood. In this study, we used intestinal organoid …
variable for reasons that are not understood. In this study, we used intestinal organoid …