[HTML][HTML] Αlpha-thalassemia: A practical overview
Abstract α-Thalassemia is an inherited blood disorder characterized by decreased synthesis
of α-globin chains that results in an imbalance of α and β globin and thus varying degrees of …
of α-globin chains that results in an imbalance of α and β globin and thus varying degrees of …
Global, regional, and national burden of thalassemia, 1990–2021: a systematic analysis for the global burden of disease study 2021
Y Tuo, Y Li, Y Li, J Ma, X Yang, S Wu, J Jin, Z He - Eclinicalmedicine, 2024 - thelancet.com
Background Anemia is a significant contributor to the global disease burden, of which
thalassemia is the most common hereditary anaemic disease. Previous estimates were …
thalassemia is the most common hereditary anaemic disease. Previous estimates were …
Pharmacogenomics of Drugs Used in β-Thalassemia and Sickle-Cell Disease: From Basic Research to Clinical Applications
In this short review we have presented and discussed studies on pharmacogenomics (also
termed pharmacogenetics) of the drugs employed in the treatment of β-thalassemia or Sickle …
termed pharmacogenetics) of the drugs employed in the treatment of β-thalassemia or Sickle …
Addressing Thalassaemia Management from Patients' Perspectives: An International Collaborative Assessment
EC Economidou, M Angastiniotis, D Avraam… - Medicina, 2024 - mdpi.com
Background and Objectives: The effective management of chronic diseases, particularly
hereditary and rare diseases and thalassaemia, is an important indicator of the quality of …
hereditary and rare diseases and thalassaemia, is an important indicator of the quality of …
Evaluation of Mono- and Bi-Functional GLOBE-Based Vectors for Therapy of β-Thalassemia by HBBAS3 Gene Addition and Mutation-Specific RNA Interference
L Koniali, C Flouri, MI Kostopoulou, NY Papaioannou… - Cells, 2023 - mdpi.com
Therapy via the gene addition of the anti-sickling βAS3-globin transgene is potentially
curative for all β-hemoglobinopathies and therefore of particular clinical and commercial …
curative for all β-hemoglobinopathies and therefore of particular clinical and commercial …
Insights in thalassemia: from genomics to clinical practice
Thalassemia, a common inherited autosomal recessive disorder, is characterized by
inefficient or absent hemoglobin synthesis, resulting in various severities of anemia (1) …
inefficient or absent hemoglobin synthesis, resulting in various severities of anemia (1) …
Global, regional, and national burden of thalassemia during 1990‐2019: A systematic analysis of the Global Burden of Disease Study 2019
R Wang, XH Ma, ZZ Qin, XX Hu, ZY Mo… - Pediatric Blood & …, 2024 - Wiley Online Library
Introduction Thalassemia represents a significant public health challenge globally. However,
the global burden of thalassemia and the disparities associated with it remain poorly …
the global burden of thalassemia and the disparities associated with it remain poorly …
Quality of Life of Children with Thalassemia in Indonesia
R Rahmah, SNN Makiyah - IJNP (Indonesian Journal of Nursing …, 2022 - journal.umy.ac.id
Background: Thalassemia is an inherited disorder of hemoglobin (Hb) synthesis. Treatment
of thalassemia has not yet reached the level of cure. Globally, the management of …
of thalassemia has not yet reached the level of cure. Globally, the management of …
Special Issue “Personalized Medicine in Blood Disease of Children”
A Ceci, P Kountouris, A Didio, F Bonifazi - Journal of Personalized …, 2024 - mdpi.com
Personalized medicine is defined as a medical model using the characterization of
individuals' phenotypes and genotypes (eg, molecular profiling, medical imaging, and …
individuals' phenotypes and genotypes (eg, molecular profiling, medical imaging, and …
Hemoglobin β-Globin Variants In Hispanic Patients: An Institutional Experience From Dallas, Texas
M Firan, CF Timmons, JY Park, M Mitui MHA… - Hemoglobin, 2023 - Taylor & Francis
Hemoglobinopathies are the most common single-gene disorders in humans. There are
1,424 variants of human hemoglobin described with 951 involving the β-globin gene …
1,424 variants of human hemoglobin described with 951 involving the β-globin gene …