Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's
lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short …

Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous
ubiquitin proteasome system to degrade a protein of interest for therapeutic benefit. As the …

The finding that transcription occurs at chromosome ends has opened new fields of study on
the roles of telomeric transcripts in chromosome end maintenance and genome stability …

The role of telomeres in human health and disease is yet to be fully understood. The
limitations of mouse models for the study of human telomere biology and difficulties in …

The cyclic GMP‐AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway
mediates anti‐microbial innate immunity by inducing the production of type I interferons …

Abstract The Nucleosome Remodeling and Deacetylase (NuRD) complex is one of the
major chromatin remodeling complexes found in cells. It plays an important role in regulating …

Simple Summary Since it was first described over two decades ago, the Alternative
Lengthening of Telomeres (ALT) pathway has been well accepted to hold clinical …