Destroying RNA as a therapeutic approach
A Tafech, T Bassett, D Sparanese… - Current medicinal …, 2006 - ingentaconnect.com
The ability to target RNA, mRNA and viral RNA in particular, for degradation is a powerful
approach in molecular biology and pharmacology. Such approaches can be used in the …
approach in molecular biology and pharmacology. Such approaches can be used in the …
Strategies to identify potential therapeutic target sites in RNA
M Lützelberger, J Kjems - RNA Towards Medicine, 2006 - Springer
Antisense agents are powerful tools to inhibit gene expression in a sequencespecific
manner. They are used for functional genomics, as diagnostic tools and for therapeutic …
manner. They are used for functional genomics, as diagnostic tools and for therapeutic …
Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences
EW Lundblad, G Xiao, J Ko… - Proceedings of the …, 2008 - National Acad Sciences
A method of inhibiting the expression of particular genes by using external guide sequences
(EGSs) has been improved in its rapidity and specificity. Random EGSs that have 14-nt …
(EGSs) has been improved in its rapidity and specificity. Random EGSs that have 14-nt …