Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Myc is an oncogene deregulated in most—perhaps all—human cancers. Each Myc family
member, c-, L-, and N-Myc, has been connected to tumor progression and maintenance …

MYC is a master transcriptional regulator that controls almost all cellular processes. Over the
last several decades, researchers have strived to define the context-dependent …

Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought
after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth …

Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human
Diseases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In …

Abstract c-Myc is a transcription factor that is constitutively and aberrantly expressed in over
70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression …

The nuclear transcription factor c-Myc is a member of the Myc gene family with multiple
functions and located on band q24. 1 of chromosome 8. The c-Myc gene is activated by …

Abstract The c-Myc (Myc) oncoprotein is among the most attractive of cancer targets given
that it is de-regulated in the majority of tumors and that its inhibition profoundly affects their …

Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …

MYC proto-oncogene dysregulation alters metabolism, translation, and other functions in
ways that support tumor induction and maintenance. Although Myc+/− mice are healthier …