Iron overload is increasingly implicated as a contributor to the pathogenesis of COVID-19.
Indeed, several of the manifestations of COVID-19, such as inflammation, hypercoagulation …

Iron deficiency, with or without anemia, is extremely frequent worldwide, representing a
major public health problem. Iron replacement therapy dates back to the seventeenth …

Iron is a micronutrient essential for a wide range of metabolic processes in virtually all living
organisms. During infections, a battle for iron takes place between the human host and the …

Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

Although iron is one of the most abundant elements on earth, about a third of the world's
population are affected by iron deficiency. Main drivers of iron deficiency are beside the …

Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve
epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence of …

A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is
evident in the lung, where both systems must be properly controlled to maintain lung …

Iron is essential for many biological processes, however, too much or too little iron can result
in a wide variety of pathological consequences, depending on the organ system, tissue or …

COPD is driven by exogenous and endogenous oxidative stress derived from inhaled
cigarette smoke, air pollution and reactive oxygen species from dysregulated mitochondria …

Disturbances in mitochondrial structure and function in lung epithelial cells have been
implicated in the pathogenesis of various lung diseases, including chronic obstructive …