Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link
between the cardiovascular system and the immune system. Besides their commonly …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Significance: Over the past several years, oxidative post-translational modifications of
protein cysteines have been recognized for their critical roles in physiology and …

Embryonic hematopoietic stem and progenitor cells (HSPCs) robustly proliferate while
maintaining multilineage potential in vivo; however, an incomplete understanding of …

Astrocytes respond to insult with a process of cellular activation known as reactive
astrogliosis. One of the key signals regulating this phenomenon is the transcription factor …

Formation of arterial vasculature, here termed arteriogenesis, is a central process in
embryonic vascular development as well as in adult tissues. Although the process of …

Toll-like receptor 2 (TLR2) is implicated in various pathologies, mainly in terms of its function
within innate immune cells. However, TLR2 is also present in endothelial cells. Here, we …

Abnormal vascular homeostasis can lead to increased proliferation of smooth muscle cells
and deposition of extracellular matrix, resulting in neointima formation, which contributes to …

Fluid shear stress due to blood flow on the vascular endothelium regulates blood vessel
development, remodeling, physiology, and pathology [1, 2]. A complex consisting of PECAM …

Copper (Cu), an essential micronutrient, plays a fundamental role in inflammation and
angiogenesis; however, its precise mechanism remains undefined. Here we uncover a …