[HTML][HTML] Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review

J Riegger, A Schoppa, L Ruths… - Cellular & Molecular …, 2023 - Springer
During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes

J Riegger, RE Brenner - Elife, 2023 - elifesciences.org
Accumulation of dysfunctional chondrocytes has detrimental consequences on the
cartilagehomeostasis and is thus thought to play a crucial role during the pathogenesis of …

[HTML][HTML] Assessing the causal associations of different types of statins use and knee/hip osteoarthritis: A Mendelian randomization study

X Chen, X Huang, Y Liu, Z Zhang, J Chen - Plos one, 2024 - journals.plos.org
Objective This study comprehensively evaluated the causal relationship between different
types of statins use and knee/hip osteoarthritis (OA) using a two-sample and multivariate …

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by promoting the release of pro …

S Maurer, V Kirsch, L Ruths, RE Brenner, J Riegger - bioRxiv, 2024 - biorxiv.org
Cellular senescence is associated with various age-related disorders and is assumed to
play a major role in the pathogenesis of osteoarthritis (OA). Based on this, we tested a …

Análise in vitro do efeito da sinvastatina como tratamento da osteoartrite da articulação temporomandibular

AMN Santos - 2022 - repositorio.ufal.br
RESUMO A osteoartrite consiste na degeneração musculoesquelética e da cartilagem,
incluindo remodelação do tecido ósseo condilar, sendo uma das formas mais comuns das …