The rapid development of new generation sequencing technology has deepened the
understanding of genomes and functional products. RNA-sequencing studies in mammals …

Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

Post-translational modifications (PTMs) play significant roles in regulating protein structure,
activity and function, and they are closely involved in various pathologies. Therefore, the …

Inflammation that complicates many autoimmune diseases, such as multiple sclerosis (MS),
has been correlated to abnormal differentiation of Th17 cells. However, the reasons that …

Background: Polycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3
Lys27, and plays crucial roles during development and diseases in numerous systems. Its …

Background Metabolites disrupted by abnormal state of human body are deemed as the
effect of diseases. In comparison with the cause of diseases like genes, these markers are …

Abstract Motivation Long non-coding RNAs (lncRNAs) are an enormous collection of
functional non-coding RNAs. Over the past decades, a large number of novel lncRNA genes …

Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by
phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro …

Background Similar diseases are always caused by similar molecular origins, such as
diasease-related protein-coding genes (PCGs). And the molecular associations reflect their …

Multilayer networks provide an efficient tool for studying complex systems, and with current,
dramatic development of bioinformatics tools and accumulation of data, researchers have …