Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque
present on kidney papillary surfaces. Similar to the plaques formed during vascular …

Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …

Renal stone disease is a frequent condition, causing a huge burden on health care systems
globally. Calcium-based calculi account for around 75% of renal stone disease and the …

Randall plaques (RPs) can contribute to the formation of idiopathic calcium oxalate (CaOx)
kidney stones; however, genes related to RP formation have not been identified. We …

The second near-infrared window emission (1.0–1.7 μm, NIR-II) has received extensive
attention with the advantages of negligible tissue scattering, reduced autofluorescence, and …

In our previous report, M2-macrophage (Mφs) deficient mice showed increased renal
calcium oxalate (CaOx) crystal formation; however, the role of Mφs-related-cytokines and …

The insect excretory system contains two organ systems acting in concert: the Malpighian
tubules and the hindgut perform essential roles in excretion and ionic and osmotic …

Highlights•Metal ions play multiple roles in osmoregulation and homeostasis.•Many metals
are cofactors of metalloenzymes.•Ion balance underpins environmental resilience, for …

Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome,
gout and kidney stones. Despite frequent occurrence of these disorders, the genetic …

Maintenance of metal homeostasis is crucial for many different enzymatic activities and in
turn for cell function and survival. In addition, cells display detoxification and protective …