Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
Evolution of partial resistance to artemisinins in malaria parasites in Uganda
MD Conrad, V Asua, S Garg… - … England Journal of …, 2023 - Mass Medical Soc
Abstract Background Partial resistance of Plasmodium falciparum to the artemisinin
component of artemisinin-based combination therapies, the most important malaria drugs …
component of artemisinin-based combination therapies, the most important malaria drugs …
Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical …
RW van der Pluijm, M Imwong, NH Chau… - The Lancet infectious …, 2019 - thelancet.com
Background The emergence and spread of resistance in Plasmodium falciparum malaria to
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …
Malaria in 2022: Increasing challenges, cautious optimism
P Jagannathan, A Kakuru - Nature communications, 2022 - nature.com
Malaria cases and deaths remain unacceptably high and are resurgent in several settings,
though recent developments inspire optimism. This includes the approval of the world's first …
though recent developments inspire optimism. This includes the approval of the world's first …
Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre …
Background Artemisinin and partner-drug resistance in Plasmodium falciparum are major
threats to malaria control and elimination. Triple artemisinin-based combination therapies …
threats to malaria control and elimination. Triple artemisinin-based combination therapies …
The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study
Background Evidence suggests that the PfKelch13 mutations that confer artemisinin
resistance in falciparum malaria have multiple independent origins across the Greater …
resistance in falciparum malaria have multiple independent origins across the Greater …
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda
Artemisinin partial resistance may facilitate selection of Plasmodium falciparum resistant to
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
combination therapy partner drugs. We evaluated 99 P. falciparum isolates collected in 2021 …
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness
The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …
falciparum malaria parasites has led to widespread treatment failures across Southeast …
Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study
Summary Background The Greater Mekong subregion is a recurrent source of antimalarial
drug resistance in Plasmodium falciparum malaria. This study aimed to characterise the …
drug resistance in Plasmodium falciparum malaria. This study aimed to characterise the …