Immune responses need to be controlled for optimal protective immunity and tolerance.
Coinhibitory pathways in the B7-CD28 family provide critical inhibitory signals that regulate …

Fine-tuning the immune response and maintaining tolerance to self-antigens involves a
complex network of co-stimulatory and co-inhibitory molecules. The recent FDA approval of …

V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a negative immune-
checkpoint protein that suppresses T-cell responses. To determine whether VISTA …

The presence of two dedicated phagocytic cells working cooperatively represents an
advantageous innate immune strategy that allows the efficient and safe utilization of …

In the past few years, the field of cancer immunotherapy has made great progress and is
finally starting to change the way cancer is treated. We are now learning that multiple …

B7‐H3 and B7‐H4 belong to a new class of immune regulatory molecules, which primarily
execute their functions in peripheral tissues to fine tune immune responses in target organs …

Neutrophils have historically been characterized as first responder cells vital to host survival
because of their ability to contain and eliminate bacterial and fungal pathogens. However …

Objective Immune escape plays an important role in tumor progression. In the present study,
the expression of B7-H1, B7-H4 and Foxp3 involved in immune escape in gastric carcinoma …

The interactions between B7 molecules and CD28-family receptors are crucial in the
regulation of adaptive cellular immunity. In cancer, the aberrant expression of co-inhibitory …

Severe sepsis is one of the leading causes of death worldwide. High mortality rates in sepsis
are frequently associated with neutropenia. Despite the central role of neutrophils in innate …