Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Objective To develop a scientifically sound and clinically relevant evidence-based guideline
for the treatment of painful diabetic neuropathy (PDN). Methods We performed a systematic …

In Diabetes, the chronic hyperglycemia and associated complications affecting peripheral
nerves are one of the most commonly occurring microvascular complications with an overall …

ABSTRACT The American Association of Clinical Endocrinologists/American College of
Endocrinology Medical Guidelines for Clinical Practice are systematically developed …

The global epidemic of prediabetes and diabetes has led to a corresponding epidemic of
complications of these disorders. The most prevalent complication is neuropathy, of which …

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging
supplements, and even pet food. It is well-defined as a therapy for preventing diabetic …

Background The molecular nature of lipoic acid (LA) clarifies its capability of taking part to a
variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is …

Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …