Increasing evidence suggests that activation of the complement system plays a key role in
the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a …

The complex pathophysiologic interplay between SARS-CoV-2 infection and complement
activation is the subject of active investigation. It is clinically mirrored by the occurrence of …

Severe COVID-19 is linked to both dysfunctional immune response and unrestrained
immunopathology, and it remains unclear whether T cells contribute to disease pathology …

Complement plays an important role in the direct defense to pathogens, but can also
activate immune cells and the release of pro-inflammatory cytokines. However, in critically ill …

Introduction While complement is a contributor to disease severity in severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

Patients with sickle cell disease (SCD) have ongoing hemolysis that promotes endothelial
injury, complement activation, inflammation, vaso-occlusion, ischemia-reperfusion …

Abstract Coronavirus disease 2019 (COVID-19) causes acute microvascular thrombosis in
both venous and arterial structures which is highly associated with increased mortality. The …

Overactivation of the complement system has been characterized in severe COVID-19
cases. Complement components are known to trigger NETosis via the coagulation cascade …

Coronavirus infectious disease-19 (COVID-19) is a pandemic characterized by serious lung
disease and thrombotic events in the venous and circulation trees, which represent a …