Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1 β and IL-18 and induces …

Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …

High blood pressure is present in more than one billion adults worldwide and is the most
important modifiable risk factor of death resulting from cardiovascular disease. While many …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Aldosterone is a mineralocorticoid hormone that controls body fluid and electrolyte balance.
Excess aldosterone is associated with cardiovascular and metabolic diseases. Inflammation …

Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory
system. Atherosclerosis is its major underlying cause. CVDs are chronic and can remain …

Although systemic hypertension affects a large proportion of the population, its etiology
remains poorly defined. Emerging evidence supports the concept that immune cells become …