Passage of systemically delivered pharmacological agents into the brain is largely blocked
by the blood-brain-barrier (BBB), an organotypic specialization of brain endothelial cells …

SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and
2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in …

Suspension and imaging cytometry techniques that simultaneously measure hundreds of
cellular features are powering a new era of cell biology and transforming our understanding …

Background Preclinical studies require models that recapitulate the cellular diversity of
human tumors and provide insight into the drug sensitivities of specific cellular populations …

Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the
most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the …

Nervous system cancers are the 10th leading cause of death worldwide, many of which are
difficult to diagnose and exhibit varying degrees of treatment resistance. The limitations of …

Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack
of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with CAF …

Glioblastoma (GBM) is the most frequent malignant brain tumor, the relapse of which is
unavoidable following standard treatment. However, the effective treatment for recurrent …

脑胶质瘤(glioma) 是中枢神经系统最常见的内在肿瘤, 具有发病率高, 预后较差等特点.
本研究旨在鉴定多形性胶质母细胞瘤(glioblastoma multiforme, GBM) 和低级别胶质瘤(lower …

Background Non-enhancing (NE) infiltrating tumor cells beyond the contrast-enhancing (CE)
bulk of tumor are potential propagators of recurrence after gross total resection of high-grade …