Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

This review summarizes the trends in the formation of complex or not so complex
heterocyclic structures through 1, 3-dipolar cycloadditions of azomethine ylides. Diastereo …

In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes
mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine …

A highly efficient, eco-friendly protocol has been developed for synthesis of spirooxindole-
pyran derivatives via one-pot, three-component reaction of isatins, malononitrile, and …

An efficient diastereoselective route is developed to get access to novel spiropyrrolo [1, 2-a]
isoquinoline-oxindole skeletons by a one-pot three-component [3+ 2] cycloaddition reaction …

Background: Antibiotic resistance is one of the biggest threats to global health today, leading
to higher medical costs and increased mortality. Because of the emergence and rapid …

In this study, the Monte Carlo method was applied for quantitative structure-activity
relationship of novel steroidal spiro-oxindoles as potent antiproliferative inhibitors against …

In recent years, N-heterocyclic carbenes (NHCs) have established themselves as a
masterful and promising type of organocatalyst for the speedy construction of medicinally …

Polycyclic fused indoline derivatives, specifically those bearing tertiary or quaternary carbon
stereocenters at C2 and C3 positions, stand as an important class of nitrogen‐containing …

A new bifunctional squaramide organocatalyst derived from l-proline mediated the first
enantioselective synthesis of dihydrospiro [indoline-3, 4′-pyrano [2, 3-c] pyrazole] …