The nonsteroidal antiinflammatory drug diclofenac causes rare but significant cases of
serious hepatotoxicity, typically with a delayed onset (> 1–3 months). Because there is no …

Idiosyncratic drug-induced liver injury (DILI) is a major clinical problem and poses a
considerable challenge for drug development as an increasing number of successfully …

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with idiosyncratic
hepatotoxicity in susceptible patients. The molecular mechanisms underlying this toxicity …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Certain drugs containing a nitroaromatic moiety (eg, tolcapone, nimesulide, nilutamide,
flutamide, nitrofurantoin) have been associated with organ-selective toxicity including rare …

We described the effects of nimesulide (N-[4-nitro-2-phenoxyphenyl]-methanesulfonamide)
and its reduced metabolite in isolated rat hepatocytes. Nimesulide stimulated the succinate …

Nimesulide, a preferential COX-2 inhibitor, has been associated with rare idiosyncratic
hepatotoxicity. The underlying mechanisms of liver injury are unknown, but experimental …

Animal models of human disease have been widely used in drug discovery, but they are
rarely utilized in toxicological research and screening (except for transgenic models in …

Drug-induced liver injury (DILI) induced by nonsteroidal antiinflammatory drugs (NSAIDs) is
clearly idiosyncratic (ie, host-dependent). Therefore, a discussion on mechanisms …

Nimesulide (NIM), a widely used nonsteroidal anti-inflammatory drug (NSAID), is known to
interfere with mitochondrial physiology and to cause idiosyncratic hepatotoxicity. In this …