Head and neck squamous cell carcinomas (HNSCC) develop in the mucosal lining of the
upper-aerodigestive tract. In carcinogen-induced HNSCC, tumors emerge from …

Head and neck squamous cell carcinomas (HNSCCs) coincide with poor survival rates. The
lack of driver oncogenes complicates the development of targeted treatments for HNSCC …

Introduction Head and neck squamous cell carcinomas (HNSCC) arise in the mucosal lining
of the upper aerodigestive tract. Risk factors are exogenous carcinogen exposure, human …

Novel therapeutic strategies for non-small-cell lung cancer (NSCLC) are urgently needed.
RNA splicing, orchestrated by the spliceosome, is deregulated in many forms of cancer …

Loss of function of BRCA1-associated protein 1 (BAP1) is observed in about 50% of
malignant pleural mesothelioma (MPM) cases. The aim of this study was to investigate …

The progression of anchorage-dependent epithelial cells to anchorage-independent growth
represents a critical hallmark of malignant transformation. Using an in vitro model of human …

The core spliceosomal Sm proteins were recently proposed as cancer-selective lethal
targets in non-small cell lung cancer (NSCLC). In contrast, the loss of the commonly mutated …

Two complimentary approaches are widely used to study gene function in zebrafish:
induction of genetic mutations, usually using targeted nucleases such as CRISPR/Cas9, and …

Fanconi anaemia (FA) is a rare chromosomal-instability syndrome caused by mutations of
any of the 22 known FA DNA-repair genes. FA individuals have an increased risk of head …

Background CRISPR screens provide large-scale assessment of cellular gene functions.
Pooled libraries typically consist of several single guide RNAs (sgRNAs) per gene, for a …