Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs)
that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are …

The discovery of the central role played by the protein alpha-synuclein in Parkinson's
disease and other Lewy body brain disorders has had a great relevance in the …

Mutations in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, are
among the most common known genetic risk factors for the development of Parkinson …

Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two
hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau …

Abstract Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets
histones and many non-histone proteins and participates in various physiological functions …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

Abstract Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic
target in Parkinson's disease. Aggregated α-syn is present in sporadic Parkinson's disease …

Abstract α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …

Alpha-synuclein is a component of Lewy bodies, the pathological hallmark of Parkinson's
disease (PD), and is also mutated in familial PD. Here, by extensively analyzing PD patient …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects
elderly people and constitutes a major source of disability worldwide. Notably, the …