Liquid phase partitioning in virus replication: observations and opportunities
C Wu, AS Holehouse, DW Leung… - Annual Review of …, 2022 - annualreviews.org
Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …
of these structures on virus replication is poorly understood. Recent research supports …
5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons
5-methylcytosine (m5C) is one of the most prevalent modifications of RNA, playing important
roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA …
roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA …
[HTML][HTML] The emerging role of RNA modifications in the regulation of antiviral innate immunity
J Tong, W Zhang, Y Chen, Q Yuan, NN Qin… - Frontiers in …, 2022 - frontiersin.org
Posttranscriptional modifications have been implicated in regulation of nearly all biological
aspects of cellular RNAs, from stability, translation, splicing, nuclear export to localization …
aspects of cellular RNAs, from stability, translation, splicing, nuclear export to localization …
Physiological functions of RIG-I-like receptors
M Yoneyama, H Kato, T Fujita - Immunity, 2024 - cell.com
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …
responses and have immense physiological importance. In this review, we first summarize …
[PDF][PDF] Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex
RJJ Jansens, R Verhamme, AH Mirza… - Cell reports, 2022 - cell.com
Chemical modifications of mRNA, the so-called epitranscriptome, represent an additional
layer of post-transcriptional regulation of gene expression. The most common …
layer of post-transcriptional regulation of gene expression. The most common …
[HTML][HTML] RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
WW Liu, SQ Zheng, T Li, YF Fei, C Wang… - … and Targeted Therapy, 2024 - nature.com
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis
requirements of cells. Relevant studies have been constantly making inroads in our …
requirements of cells. Relevant studies have been constantly making inroads in our …
Challenges to mapping and defining m6A function in viral RNA
SM Horner, MG Thompson - RNA, 2024 - rnajournal.cshlp.org
Viral RNA molecules contain multiple layers of regulatory information. This includes features
beyond the primary sequence, such as RNA structures and RNA modifications, including N6 …
beyond the primary sequence, such as RNA structures and RNA modifications, including N6 …
Recent insights into N6-methyladenosine during viral infection
SM Horner, JV Reaves - Current Opinion in Genetics & Development, 2024 - Elsevier
Highlights•m 6 A regulates viral and cellular RNA molecules during infection, including
SARS-CoV-2.•Viruses can alter the localization and function of m 6 A-machinery proteins.•m …
SARS-CoV-2.•Viruses can alter the localization and function of m 6 A-machinery proteins.•m …
[HTML][HTML] Research progress on the role of RNA N6-methyladenosine methylation in HCV infection
Y Ge, S Tang, T Xia, C Shi - Virology, 2023 - Elsevier
Hepatitis C virus (HCV) is a positive-stranded RNA virus causing chronic liver diseases. The
chemical modification of RNA is a research hotspot in related fields in recent years …
chemical modification of RNA is a research hotspot in related fields in recent years …