The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Surgery
followed by chemotherapy and radiotherapy remains the standard treatment strategy for …

Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM),
but inevitably induces poorly understood global changes in GBM and its microenvironment …

Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can
impact human health and well-being as a consequence of, for example, the side effects of …

Targeting the tumour immune microenvironment (TIME) by cancer immunotherapy has led to
improved patient outcomes. However, response to these treatments is heterogeneous and …

The dense and heterogeneous physical network of the extracellular matrix (ECM) in tumors
represents a formidable barrier that limits intratumor drug delivery and the therapeutic …

Advances in cancer biology are revealing the importance of the cancer cell
microenvironment on tumorigenesis and cancer progression. Hyaluronan (HA), the main …

Simple Summary The biological pathways underlying glioblastoma malignancy and
radioresistance are still unclear. In this review, we describe the role of the hypoxic …

The invasive capacity of GBM is one of the key tumoral features associated with treatment
resistance, recurrence, and poor overall survival. The molecular machinery underlying GBM …