[HTML][HTML] Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies

M Elmowafy, MM Al-Sanea - Saudi Pharmaceutical Journal, 2021 - Elsevier
NLCs have provoked the incessant impulsion for the development of safe and valuable drug
delivery systems owing to their exceptional physicochemical and then biocompatible …

Nanostructured lipid carriers: Promising drug delivery systems for future clinics

A Beloqui, MÁ Solinís, A Rodríguez-Gascón… - … , biology and medicine, 2016 - Elsevier
During the past decade, the number of studies describing nanostructured lipid carriers
(NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation …

Freeze-drying of nanoparticles: How to overcome colloidal instability by formulation and process optimization

E Trenkenschuh, W Friess - European journal of pharmaceutics and …, 2021 - Elsevier
Lyophilization of nanoparticle (NP) suspensions is a promising technology to improve
stability, especially during long-term storage, and offers new routes of administration in solid …

[HTML][HTML] Long-term storage of lipid-like nanoparticles for mRNA delivery

P Zhao, X Hou, J Yan, S Du, Y Xue, W Li, G Xiang… - Bioactive materials, 2020 - Elsevier
Lipid-like nanoparticles (LLNs) have been extensively explored for messenger RNA (mRNA)
delivery in various biomedical applications. However, the long-term storage of these …

Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery

S Das, A Chaudhury - Aaps Pharmscitech, 2011 - Springer
Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to
improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially …

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

RL Ball, P Bajaj, KA Whitehead - International journal of …, 2017 - Taylor & Francis
The broadest clinical application of siRNA therapeutics will be facilitated by drug-loaded
delivery systems that maintain stability and potency for long times under ambient conditions …

[HTML][HTML] Design of lipid-based nanoparticles for delivery of therapeutic nucleic acids

MCP Mendonça, A Kont, PS Kowalski… - Drug Discovery …, 2023 - Elsevier
The successful development of nonviral delivery systems for nucleic acids has been
reported extensively over the past number of years. Among them, lipid-based nanoparticles …

A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability

EA Voigt, A Gerhardt, D Hanson, MF Jennewein… - npj Vaccines, 2022 - nature.com
Abstract mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and
have since demonstrated high efficacy against serious illness and death. However …

Nanostructured lipid carriers (NLCs) for drug delivery and targeting

CL Fang, SA Al-Suwayeh… - Recent patents on …, 2013 - ingentaconnect.com
Nanostructured lipid carriers (NLCs) are drug-delivery systems composed of both solid and
liquid lipids as a core matrix. It was shown that NLCs reveal some advantages for drug …

Freeze-drying: A flourishing strategy to fabricate stable pharmaceutical and biological products

KK Abla, MM Mehanna - International journal of pharmaceutics, 2022 - Elsevier
Freeze-drying (FD) of nanoparticles, microorganisms, genes, and vaccines is an auspicious
technique used to enhance long-term stability and facilitate transportation mainly for …