Diabetes and cognitive impairment

LA Zilliox, K Chadrasekaran, JY Kwan… - Current diabetes …, 2016 - Springer
Abstract Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with
reduced performance on multiple domains of cognitive function and with evidence of …

[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis

CY Santos, PJ Snyder, WC Wu, M Zhang… - Alzheimer's & Dementia …, 2017 - Elsevier
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies

E Pedditizi, R Peters, N Beckett - Age and ageing, 2016 - academic.oup.com
Scope: it has been suggested that overweight/obesity as a risk factor for incident dementia
differs between mid-life and later life. We performed a systematic review and meta-analysis …

Epidemiology of Alzheimer disease

R Mayeux, Y Stern - Cold Spring Harbor …, 2012 - perspectivesinmedicine.cshlp.org
The global prevalence of dementia has been estimated to be as high as 24 million, and is
predicted to double every 20 years until at least 2040. As the population worldwide …

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

Z Cai, MD Hussain, LJ Yan - International Journal of Neuroscience, 2014 - Taylor & Francis
Compelling evidence from basic molecular biology has demonstrated the dual roles of
microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are …

Epidemiology of Alzheimer disease

C Reitz, C Brayne, R Mayeux - Nature Reviews Neurology, 2011 - nature.com
The global prevalence of dementia is estimated to be as high as 24 million, and is predicted
to double every 20 years through to 2040, leading to a costly burden of disease. Alzheimer …

Obesity and cognitive decline: role of inflammation and vascular changes

JCD Nguyen, AS Killcross, TA Jenkins - Frontiers in neuroscience, 2014 - frontiersin.org
The incidence of obesity in middle age is increasing markedly, and in parallel the
prevalence of metabolic disorders including cardiovascular disease and type II diabetes is …

Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan

CR Jung, YT Lin, BF Hwang - Journal of Alzheimer's Disease, 2015 - content.iospress.com
Several studies with animal research associate air pollution in Alzheimer's disease (AD)
neuropathology, but the actual impact of air pollution on the risk of AD is unknown. Here, this …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …