Genetic correlations of polygenic disease traits: from theory to practice
W Van Rheenen, WJ Peyrot, AJ Schork… - Nature Reviews …, 2019 - nature.com
The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …
contribute to a better understanding of the shared biological pathways and/or the causality …
Genetics and gene-environment interactions in childhood and adult onset asthma
E Morales, D Duffy - Frontiers in pediatrics, 2019 - frontiersin.org
Asthma is a heterogeneous disease that results from the complex interaction between
genetic factors and environmental exposures that occur at critical periods throughout life. It …
genetic factors and environmental exposures that occur at critical periods throughout life. It …
COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study
C Li, J Liu, J Lin, H Shang - Translational psychiatry, 2022 - nature.com
Emerging evidence has suggested a close correlation between COVID-19 and
neurodegenerative disorders. However, whether there exists a causal association and the …
neurodegenerative disorders. However, whether there exists a causal association and the …
An integrated framework for local genetic correlation analysis
J Werme, S van der Sluis, D Posthuma, CA de Leeuw - Nature genetics, 2022 - nature.com
Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared
genetic basis. Traditionally, rg is studied globally, considering only the average of the …
genetic basis. Traditionally, rg is studied globally, considering only the average of the …
Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements
Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric
genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …
genetic studies and limited knowledge of shared causal variants. Leveraging regulatory …
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
Local genetic correlation quantifies the genetic similarity of complex traits in specific
genomic regions. However, accurate estimation of local genetic correlation remains …
genomic regions. However, accurate estimation of local genetic correlation remains …
Population-specific causal disease effect sizes in functionally important regions impacted by selection
Many diseases exhibit population-specific causal effect sizes with trans-ethnic genetic
correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We …
correlations significantly less than 1, limiting trans-ethnic polygenic risk prediction. We …
A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
The development of polygenic risk scores (PRSs) has proved useful to stratify the general
European population into different risk groups. However, PRSs are less accurate in non …
European population into different risk groups. However, PRSs are less accurate in non …
Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals
Here we report a large genome-wide association study (GWAS) for longitudinal smoking
phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we …
phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we …
Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data
Individuals with psychiatric disorders have elevated rates of autoimmune comorbidity and
altered immune signaling. It is unclear whether these altered immunological states have a …
altered immune signaling. It is unclear whether these altered immunological states have a …