In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly
regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo …

Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …

Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which
together with estradiol regulates gonadotropin secretion, prepares the endometrium for …

Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

All mammalian uteri contain glands in the endometrium that develop only or primarily after
birth. Gland development or adenogenesis in the postnatal uterus is intrinsically regulated …

In women, endometrial morphology and function undergo characteristic changes every
menstrual cycle. These changes are crucial for perpetuation of the species and are …

Uniquely among adult tissues, the human endometrium undergoes cyclical shedding, scar-
free repair and regeneration during a woman's reproductive life. Therefore, it presents an …

To allow selection of embryos for transfer after in vitro fertilization, ovarian stimulation is
usually carried out with exogenous gonadotropins. To compensate for changes induced by …

The mucosal immune system in the female reproductive tract (FRT) has evolved to meet the
unique requirements of dealing with sexually transmitted bacterial and viral pathogens …

All mammalian uteri contain endometrial glands that synthesize or transport and secrete
substances essential for survival and development of the conceptus (embryo/fetus and …