Background The quantity of iron in body is carefully regulated, primarily by control of iron
absorption, and excess total body iron can be extremely toxic. Since humans have no …

Deferiprone is an orally active iron chelator which has emerged from an extensive search for
new treatment of iron overload. Comparative studies have shown that at comparable doses …

Despite receiving no or only occasional blood transfusions, patients with non‐transfusion‐
dependent thalassemia (NTDT) have increased intestinal iron absorption and can …

The clinical approach to thalassemia and hemoglobinopathies, specifically Sickle Cell
Disease (SCD), based on transfusions, iron chelation and bone marrow transplantation has …

Chelation therapy with new drugs prevents cardiac damage and improves the survival of
thalassemia patients. Liver diseases have emerged as a critical clinical issue. Chronic liver …

Purpose Hepatic iron content (HIC) quantification via transverse relaxation rate (R2*)‐MRI
using multi‐gradient echo (mGRE) imaging is compromised toward high HIC or at higher …

SUMMARY ß-thalassemia is an inherited disorder of hemoglobin synthesis characterized by
deficient synthesis of the ß-globin chain that causes severe anemia. Over the years, the …

Objectives: Hepatitis C virus (HCV) is the major cause of post-transfusion hepatitis infection
(PTH). Patients with thalassemia major are at high risk of hepatitis C due to the blood …

Progression of liver fibrosis in patients with hemoglobinopathies is strongly related to the
severity of iron overload and the presence of chronic hepatitis C virus (HCV) infection …

β-Thalassemia (β-thal) is associated with abnormal synthesis of hemoglobin (Hb). Repeated
blood transfusions in patients with β-thal major (β-TM) leads to an enhanced generation of …