ALCAM/CD166: A pleiotropic mediator of cell adhesion, stemness and cancer progression

F Ferragut, VS Vachetta, MF Troncoso… - Cytokine & Growth …, 2021 - Elsevier
Abstract Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a glycoprotein
involved in homotypic and heterotypic cell adhesion. ALCAM can be proteolytically cleaved …

[HTML][HTML] The prognostic and clinical value of CD44 in colorectal cancer: a meta-analysis

Z Wang, Y Tang, L Xie, A Huang, C Xue, Z Gu… - Frontiers in …, 2019 - frontiersin.org
Background: CD44 is widely used as a putative cancer stem cells (CSCs) marker for
colorectal cancer (CRC). However, the prognostic role of CD44 in CRC remains …

[HTML][HTML] Bile acid: a potential inducer of colon cancer stem cells

L Farhana, P Nangia-Makker, E Arbit, K Shango… - Stem Cell Research & …, 2016 - Springer
Background Although the unconjugated secondary bile acids, specifically deoxycholic acid
(DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the …

[HTML][HTML] Recent updates on the significance of KRAS mutations in colorectal cancer biology

L László, A Kurilla, T Takács, G Kudlik, K Koprivanacz… - Cells, 2021 - mdpi.com
The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this
review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming …

Revolutionizing the landscape of colorectal cancer treatment: the potential role of immune checkpoint inhibitors

MF Tolba - International journal of cancer, 2020 - Wiley Online Library
Colorectal cancer (CRC) represents the third cause of cancer‐related mortalities worldwide.
The progression of CRC to the metastatic phase significantly compromises the overall …

[HTML][HTML] Expression profiling of circulating tumor cells in pancreatic ductal adenocarcinoma patients: biomarkers predicting overall survival

C Amantini, MB Morelli, M Nabissi, F Piva… - Frontiers in …, 2019 - frontiersin.org
The interest in liquid biopsy is growing because it could represent a non-invasive prognostic
or predictive tool for clinical outcome in patients with pancreatic ductal adenocarcinoma …

[HTML][HTML] Portrait of cancer stem cells on colorectal cancer: molecular biomarkers, signaling pathways and miRNAome

A Angius, AM Scanu, C Arru, MR Muroni… - International journal of …, 2021 - mdpi.com
Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and about 20% is
metastatic at diagnosis and untreatable. Increasing evidence suggests that the …

[HTML][HTML] The clinical and theranostic values of activated leukocyte cell adhesion molecule (ALCAM)/CD166 in human solid cancers

Y Yang, AJ Sanders, QP Dou, DG Jiang, AX Li… - Cancers, 2021 - mdpi.com
Simple Summary ALCAM (activated leukocyte cell adhesion molecule) is an important
regulator in human cancers, particularly solid tumours. Its expression in cancer tissues has …

[HTML][HTML] Inhibition of colon cancer K-RasG13D mutation reduces cancer cell proliferation but promotes stemness and inflammation via RAS/ERK pathway

Y Qi, H Zou, XH Zhao, J Kapeleris… - Frontiers in …, 2022 - frontiersin.org
K-Ras is a well-studied oncogene, and its mutation is frequently found in epithelial cancers
like pancreas, lung, and colorectal cancers. Cancer cells harboring K-Ras mutations are …

[HTML][HTML] Prognostic value of CD44 and its isoforms in advanced cancer: a systematic meta-analysis with trial sequential analysis

S Han, T Huang, W Li, X Wang, X Wu, S Liu… - Frontiers in …, 2019 - frontiersin.org
Objective: Cancer stem cell marker CD44 and its variant isoforms (CD44v) may be
correlated with tumor growth, metastasis, and chemo-radiotherapy resistance. However, the …