Zinc is a trace metal ion in the central nervous system that plays important biological roles,
such as in catalysis, structure, and regulation. It contributes to antioxidant function and the …

The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well
understood. Coenzyme A participates in more than 100 different catabolic and anabolic …

Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation
and compose the complex nervous system. Wnt signaling is thought to control the balance of …

Peripheral nerve injury‐induced spinal microglial proliferation plays a pivotal role in
neuropathic pain. So far, key intracellular druggable molecules involved in this process are …

Down syndrome (DS) is a genetic disease that occurs due to an aneuploidy of human
chromosome 21. Trisomy of chromosome 21 is a primary genetic cause of developmental …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

Down syndrome (DS) caused by a trisomy of chromosome 21 (HSA21), is the most common
genetic developmental disorder, with an incidence of 1 in 800 live births. Its phenotypic …

The ongoing epidemics of metabolic diseases and increase in the older population have
increased the incidences of neurodegenerative diseases. Evidence from murine and cell …

Background/Aims: Pulmonary arterial hypertension (PAH) is a severe and debilitating
disease characterized by remodeling of the pulmonary vessels, which is driven by excessive …