Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a fast-
growing technique for visualization of the spatial distribution of the small molecular and …

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass
spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the …

Cells are the most basic structural units that play vital roles in the functioning of living
organisms. Analysis of the chemical composition and content of a single cell plays a vital …

Anaerobic microorganisms (anaerobes) possess a fascinating metabolic versatility. This
characteristic makes anaerobes interesting candidates for physiological studies and …

Abstract BACKGROUND MALDI-TOF mass spectrometry (MS) is set to make inroads into
clinical chemistry because it offers advantages over other analytical platforms. These …

Mass spectrometry imaging (MSI) is a powerful label‐free analysis technique that can
provide simultaneous spatial distribution of multiple compounds in a single experiment. By …

The applications of organic matrices for matrix assisted laser desorption/ionization mass
spectrometry (MALDI-MS) are reviewed. Recent advances of MALDI-MS using organic …

Tissue distribution and quantitative analysis of small molecules is a key to assess the
mechanism of drug action and evaluate treatment efficacy. The prodrug irinotecan (CPT-11) …

Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass
spectrometry (IMS) enables localization of analytes of interest along with histology. More …