Abstract The Infectious Diseases Society of America (IDSA) is committed to providing up-to-
date guidance on the treatment of antimicrobial-resistant infections. A previous guidance …

Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

Background Due to the substantial increase in the use of disinfectants containing quaternary
ammonion compounds (QACs) in healthcare and community settings during the COVID-19 …

Despite being members of gut microbiota, Enterobacteriaceae are associated with many
severe infections such as bloodstream infections. The β-lactam drugs have been the …

The β-lactams are the most widely used antibacterial agents worldwide. These antibiotics, a
group that includes the penicillins and cephalosporins, are covalent inhibitors that target …

Class C β-lactamases or cephalosporinases can be classified into two functional groups (1,
1e) with considerable molecular variability (≤ 20% sequence identity). These enzymes are …

Antibiotic resistance is recognised as a global threat to human health by national healthcare
agencies, governments and medical societies, as well as the World Health Organization …

Background Carbapenems are recommended treatment for serious infections caused by
AmpC-producing gram-negative bacteria but can select for carbapenem resistance …

The history of modern medicine cannot be written apart from the history of the antibiotics.
Antibiotics are cytotoxic secondary metabolites that are isolated from Nature. The …

Taniborbactam is a novel cyclic boronate β-lactamase inhibitor in clinical development in
combination with cefepime. We assessed the in vitro activity of cefepime-taniborbactam and …