Body localization of ACE-2: on the trail of the keyhole of SARS-CoV-2

F Salamanna, M Maglio, MP Landini, M Fini - Frontiers in medicine, 2020 - frontiersin.org
The explosion of the new coronavirus (SARS-CoV-2) pandemic has brought the role of the
angiotensin converting enzyme 2 (ACE2) back into the scientific limelight. Since SARS-CoV …

A metabolic handbook for the COVID-19 pandemic

JS Ayres - Nature metabolism, 2020 - nature.com
For infectious-disease outbreaks, clinical solutions typically focus on efficient pathogen
destruction. However, the COVID-19 pandemic provides a reminder that infectious diseases …

Risk factors associated with clinical outcomes in 323 coronavirus disease 2019 (COVID-19) hospitalized patients in Wuhan, China

L Hu, S Chen, Y Fu, Z Gao, H Long… - Clinical infectious …, 2020 - academic.oup.com
Background With evidence of sustained transmission in more than 190 countries,
coronavirus disease 2019 (COVID-19) has been declared a global pandemic. Data are …

[HTML][HTML] Angiotensin-converting enzyme 2—at the heart of the COVID-19 pandemic

GY Oudit, K Wang, A Viveiros, MJ Kellner… - Cell, 2023 - cell.com
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the
COVID-19 pandemic, it has become one of the most therapeutically targeted human …

SARS-CoV-2, ACE2 expression, and systemic organ invasion

UM Ashraf, AA Abokor, JM Edwards… - Physiological …, 2021 - journals.physiology.org
A novel coronavirus disease, COVID-19, has created a global pandemic in 2020, posing an
enormous challenge to healthcare systems and affected communities. COVID-19 is caused …

ACE2: the molecular doorway to SARS-CoV-2

MM Medina-Enríquez, S Lopez-León… - Cell & bioscience, 2020 - Springer
The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new
virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different …

Worse progression of COVID‐19 in men: is testosterone a key factor?

VA Giagulli, E Guastamacchia, T Magrone, E Jirillo… - …, 2021 - Wiley Online Library
Background The novel severe acute respiratory syndrome coronavirus (SARS‐CoV‐2)
disease 2019 (COVID‐19) seems to have a worse clinical course among infected men …

Covid-19 and diabetes: a complex bidirectional relationship

H Muniangi-Muhitu, E Akalestou, V Salem… - Frontiers in …, 2020 - frontiersin.org
Covid-19 is a recently-emerged infectious disease caused by the novel severe acute
respiratory syndrome coronavirus SARS-CoV2. SARS-CoV2 differs from previous …

Diabetes and metabolic syndrome as risk factors for COVID-19

M Marhl, V Grubelnik, M Magdič, R Markovič - Diabetes & Metabolic …, 2020 - Elsevier
Background and aims Clinical evidence exists that patients with diabetes are at higher risk
for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this …

Potential role for tissue factor in the pathogenesis of hypercoagulability associated with in COVID-19

M Bautista-Vargas, F Bonilla-Abadía… - Journal of thrombosis and …, 2020 - Springer
In December 2019, a new and highly contagious infectious disease emerged in Wuhan,
China. The etiologic agent was identified as a novel coronavirus, now known as Severe …