[HTML][HTML] Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors

T Johansen, T Lamark - Journal of molecular biology, 2020 - Elsevier
Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

The ATG conjugation systems in autophagy

N Mizushima - Current opinion in cell biology, 2020 - Elsevier
Autophagosome formation and maturation involve the two ubiquitin-like systems: The ATG8
and ATG12 systems. ATG8 (LC3s and gamma-aminobutyric acid receptor–associated …

Regulation of selective autophagy: the p62/SQSTM1 paradigm

T Lamark, S Svenning, T Johansen - Essays in biochemistry, 2017 - portlandpress.com
In selective autophagy, cytoplasmic components are selected and tagged before being
sequestered into an autophagosome by means of selective autophagy receptors such as …

Roles of autophagy in oxidative stress

HR Yun, YH Jo, J Kim, Y Shin, SS Kim… - International journal of …, 2020 - mdpi.com
Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

J Mejlvang, H Olsvik, S Svenning, JA Bruun… - Journal of cell …, 2018 - rupress.org
It is not clear to what extent starvation-induced autophagy affects the proteome on a global
scale and whether it is selective. In this study, we report based on quantitative proteomics …

Digesting the expanding mechanisms of autophagy

NT Ktistakis, SA Tooze - Trends in cell biology, 2016 - cell.com
Autophagy is a catabolic 'self-eating'pathway that is emerging as a crucial integration point
in cell physiology. With its own set of genes, the autophagy pathway communicates with …

Activation and targeting of ATG8 protein lipidation

S Martens, D Fracchiolla - Cell discovery, 2020 - nature.com
ATG8 family proteins are evolutionary conserved ubiquitin-like modifiers, which become
attached to the headgroup of the membrane lipid phosphatidylethanolamine in a process …

The regulation of autophagy by calcium signals: Do we have a consensus?

MD Bootman, T Chehab, G Bultynck, JB Parys… - Cell calcium, 2018 - Elsevier
Abstract Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading
and recycling cellular constituents, and for maintenance of cell function. Autophagy initiates …

[HTML][HTML] Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes

S Kumar, R Javed, M Mudd, S Pallikkuth, KA Lidke… - Cell, 2021 - cell.com
The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used
cellular and in vitro membrane fusion analyses to show that autophagosomes are formed …