Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …

Recent advances in our understanding of both the regulation of components of the
translational machinery and the upstream signalling pathways that modulate them have …

Viruses are obligate intracellular parasites; they heavily depend on the host cell machinery
to effectively replicate and produce new progeny virus particles. Following viral infection …

The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (Mnk1 and
Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to …

The MAP kinase signal-integrating kinases or MAP kinase-interacting protein kinases
(Mnks) are activated by signaling through the oncogenic MAP kinase (ERK) pathway. The …

[Frontiers in Bioscience 5359-5374, May 1, 2008] 5359 The Mnks: MAP kinase-interacting
kinases (MAP kinase signal-integrating k Page 1 [Frontiers in Bioscience 5359-5374, May 1 …

Deregulation of protein synthesis is a common event in human cancer and a key player in
translational control is eIF4E. Elevated expression levels of eIF4E promote cancer …

There is currently a high level of interest in signalling through the mammalian target of
rapamycin (mTOR). This reflects both its key role in many cell functions and its involvement …

Glioblastoma multiforme (GBM) is the most common aggressive brain cancer with a median
survival of approximately 1 year. In a search for novel molecular targets that could be …