Mediators of the resolution of the inflammatory response

MA Sugimoto, JP Vago, M Perretti, MM Teixeira - Trends in immunology, 2019 - cell.com
The termination of inflammation is governed by endogenous molecules collectively referred
to as 'mediators of resolution'of inflammation. There is now strong evidence to suggest that …

Bone fragility during the COVID-19 pandemic: the role of macro-and micronutrients

A Moretti, S Liguori, M Paoletta… - Therapeutic …, 2023 - journals.sagepub.com
Bone fragility is the susceptibility to fracture due to poor bone strength. This condition is
usually associated with aging, comorbidities, disability, poor quality of life, and increased …

The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor axis as a key player in alveolar bone remodeling

CM Queiroz-Junior, ACPM Santos, I Galvão, GR Souto… - Bone, 2019 - Elsevier
The renin-angiotensin system (RAS), aside its classical hormonal properties, has been
implicated in the pathogenesis of inflammatory disorders. The angiotensin converting …

Xanthenone, ACE2 activator, counteracted gentamicin-induced nephrotoxicity in rats: impact on oxidative stress and ACE2/Ang-(1–7) signaling

MM Abdel-Fattah, ANAM Elgendy, WR Mohamed - Life Sciences, 2021 - Elsevier
Nephrotoxicity is a rapid deterioration of kidney function due to exposure to nephrotoxic
drugs as gentamicin. Gentamicin increases the generation of reactive oxygen species (ROS) …

Angiotensin-(1-7) promotes resolution of neutrophilic inflammation in a model of antigen-induced arthritis in mice

LC Barroso, GS Magalhaes, I Galvão, AC Reis… - Frontiers in …, 2017 - frontiersin.org
Defective resolution of inflammation may be crucial for the initiation and development of
chronic inflammatory diseases, such as arthritis. Therefore, it has been suggested that …

GLP-1 mediates regulation of colonic ACE2 expression by the bile acid receptor GPBAR1 in inflammation

M Biagioli, S Marchianò, R Roselli, C Di Giorgio… - Cells, 2022 - mdpi.com
Background & Aims: ACE2, a carboxypeptidase that generates Ang-(1-7) from Ang II, is
highly expressed in the lung, small intestine and colon. GPBAR1, is a G protein bile acid …

Modulation of brain ACE and ACE2 may be a promising protective strategy against cerebral ischemia/reperfusion injury: an experimental trial in rats

MM Abdel-Fattah, BAS Messiha… - … Schmiedeberg's archives of …, 2018 - Springer
The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological
homeostasis and disease progression. We evaluated the protective effects of the …

What do we know about the renin angiotensin system and inflammatory bowel disease?

SW Lo, JP Segal, JS Lubel, M Garg - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The renin-angiotensin system (RAS) is an important homeostatic pathway, with
emerging evidence for the impact of its components on inflammation and fibrosis in …

Onion bulb extract reduces colitis severity in mice via modulation of colonic inflammatory pathways and the apoptotic machinery

MA Khajah, KY Orabi, S Hawai, HG Sary… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance The use of nutraceutical-based products has increased in
recent years due to their demonstrated efficacy and their good safety profile. Onion is one of …

Azelaic Acid Regulates the Renin–Angiotensin System and Improves Colitis Based on Network Pharmacology and Experimentation

Y Liao, X Wu, W Luo, J Chen, Y Huang, K Ma… - ACS …, 2023 - ACS Publications
Inflammatory bowel disease (IBD), which encompasses Crohn's disease and ulcerative
colitis, has a complicated etiology that might be brought on by metabolic dysbiosis. Previous …