MgrB Mutations and Altered Cell Permeability in Colistin Resistance in Klebsiella pneumoniae

PSX Yap, WH Cheng, SK Chang, SHE Lim, KS Lai - Cells, 2022 - mdpi.com
There has been a resurgence in the clinical use of polymyxin antibiotics such as colistin due
to the limited treatment options for infections caused by carbapenem-resistant …

Farm to table: colistin resistance hitchhiking through food

A Talat, C Miranda, P Poeta, AU Khan - Archives of Microbiology, 2023 - Springer
Colistin is a high priority, last-resort antibiotic recklessly used in livestock and poultry farms.
It is used as an antibiotic for treating multi-drug resistant Gram-negative bacterial infections …

High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be …

AMS Shein, DL Wannigama, PG Higgins, C Hurst… - Scientific Reports, 2022 - nature.com
The global prevalence of colistin-resistant Klebsiella pneumoniae (ColRkp) facilitated by
chromosomal and plasmid-mediated Ara4N or PEtN-remodeled LPS alterations has steadily …

Plasmidome in mcr-1 harboring carbapenem-resistant enterobacterales isolates from human in Thailand

P Boueroy, T Wongsurawat, P Jenjaroenpun… - Scientific Reports, 2022 - nature.com
The emergence of the mobile colistin-resistance genes mcr-1 has attracted significant
attention worldwide. This study aimed to investigate the genetic features of mcr-1-carrying …

Genomic analysis of carbapenem- and colistin-resistant Klebsiella pneumoniae complex harbouring mcr-8 and mcr-9 from individuals in Thailand

R Hatrongjit, T Wongsurawat, P Jenjaroenpun… - Scientific Reports, 2024 - nature.com
The surge in mobile colistin-resistant genes (mcr) has become an increasing public health
concern, especially in carbapenem-resistant Enterobacterales (CRE). Prospective …

[HTML][HTML] Prevalence and molecular characteristics of colistin-resistant isolates among clinically isolated carbapenem-resistant Klebsiella pneumoniae in China

H Hu, Q Shi, P Zhang, J Quan, X Han, D Zhao… - International Journal of …, 2023 - Elsevier
Colistin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses health
challenges. To investigate the prevalence and molecular characteristics of colistin-resistant …

[HTML][HTML] First reported detection of the mobile colistin resistance genes, mcr-8 and mcr-9, in the Irish environment

N Cahill, B Hooban, K Fitzhenry, A Joyce… - Science of the Total …, 2023 - Elsevier
The emergence and dissemination of mobile colistin resistance (mcr) genes across the
globe poses a significant threat to public health, as colistin remains one of the last line …

First report of Klebsiella pneumoniae co-producing OXA-181, CTX-M-55, and MCR-8 isolated from the patient with bacteremia

H Ge, J Qiao, H Xu, R Liu, R Chen, C Li, X Hu… - Frontiers in …, 2022 - frontiersin.org
The worldwide spread of carbapenem-resistant Enterobacteriaceae (CRE) has led to a
major challenge to human health. In this case, colistin is often used to treat the infection …

One Health Analysis of mcr-Carrying Plasmids and Emergence of mcr-10.1 in Three Species of Klebsiella Recovered from Humans in China

MC Liu, Z Jian, W Liu, J Li, N Pei - Microbiology Spectrum, 2022 - Am Soc Microbiol
The global dissemination of the mobile colistin resistance (mcr) gene illustrates how the use
of colistin in veterinary medicine can affect human health, exemplifying the concept of One …

Prevalence, Characteristics, and Clonal Distribution of Escherichia coli Carrying Mobilized Colistin Resistance Gene mcr-1.1 in Swine Farms and Their Differences …

S Lee, JU An, JH Woo, H Song, S Yi, WH Kim… - Frontiers in …, 2022 - frontiersin.org
Global spread of Escherichia coli strains carrying the mobilized colistin resistance gene mcr-
1.1 (MCR1-EC) poses serious threats to public health. Colistin has been generally …