Carcinogenic human papillomavirus infection

M Schiffman, J Doorbar, N Wentzensen… - Nature reviews Disease …, 2016 - nature.com
Infections with human papillomavirus (HPV) are common and transmitted by direct contact.
Although the great majority of infections resolve within 2 years, 13 phylogenetically related …

Sexual dimorphism in cancer

A Clocchiatti, E Cora, Y Zhang, GP Dotto - Nature Reviews Cancer, 2016 - nature.com
The incidence of many types of cancer arising in organs with non-reproductive functions is
significantly higher in male populations than in female populations, with associated …

[HTML][HTML] Integrated genomic and molecular characterization of cervical cancer

Cancer Genome Atlas Research Network - Nature, 2017 - ncbi.nlm.nih.gov
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide.
Reported here is an extensive molecular characterization of 228 primary cervical cancers …

A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

NG Khan, J Correia, D Adiga, PS Rai… - … Science and Pollution …, 2021 - Springer
Abstract Bisphenol A [BPA;(CH 3) 2 C (C 6 H 4 OH) 2] is a synthetic chemical used as a
precursor material for the manufacturing of plastics and resins. It gained attention due to its …

Dissecting the single-cell transcriptome network of immune environment underlying cervical premalignant lesion, cervical cancer and metastatic lymph nodes

C Li, K Hua - Frontiers in immunology, 2022 - frontiersin.org
Cervical cancer (CC) is one of the most common malignancy in women worldwide. It is
characterized by a natural continuous phenomenon, that is, it is in the initial stage of HPV …

[HTML][HTML] Evasion of host immune defenses by human papillomavirus

JA Westrich, CJ Warren, D Pyeon - Virus research, 2017 - Elsevier
A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …

Single‐nucleus RNA sequencing and spatial transcriptomics reveal the immunological microenvironment of cervical squamous cell carcinoma

Z Ou, S Lin, J Qiu, W Ding, P Ren, D Chen… - Advanced …, 2022 - Wiley Online Library
The effective treatment of advanced cervical cancer remains challenging. Herein, single‐
nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics …

Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming

S Koster, RK Gurumurthy, N Kumar, PG Prakash… - Nature …, 2022 - nature.com
Coinfections with pathogenic microbes continually confront cervical mucosa, yet their
implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical …

Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers

T Xu, S Yu, J Zhang, S Wu - Journal of hematology & oncology, 2021 - Springer
Gynecological and breast cancers are a group of heterogeneous malignant tumors.
Although existing treatment strategies have ameliorated the clinical outcomes of patients …

The key differences between human papillomavirus-positive and-negative head and neck cancers: biological and clinical implications

SF Powell, L Vu, WC Spanos, D Pyeon - Cancers, 2021 - mdpi.com
Simple Summary Head and neck cancer (HNC) is the sixth most common cancer, causing
almost half a million deaths worldwide every year. The two subtypes of HNC are distinctly …